A cyclotron produces radioisotopes which the Radiochemistry Laboratory uses to make radioisotopes for non-invasive Positron Emission Tomography imaging. The Radiochemistry Laboratory synthesizes established radiotracers and assists development of novel imaging agents. The Radiochemistry Core is equpped with:
Trasis All-in-One Automated Radiosynthesizer
Produce preclinical or clinical radiopharmaceuticals on a fully automated platform.
*This list is not meant to be all-inclusive as we have a variety of other imaging agents available for preclinical and human research use. The Trasis is also an open platform machine; thus, we can produce customized radiopharmaceuticals as well. Please contact Shivashankar Khanapur with questions about radiotracer availability and production.
Custom Chemical Synthesis
The core is also capable of performing custom chemical synthesis for researchers interested in using organic small molecules in their research. Services may include:
custom chemical synthesis of precursors for radiopharmaceuticals
custom chemical synthesis of small molecules intended for research use
custom chemical synthesis of standards for HPLC identity
Hidex Automated Gamma Counter
Gamma detection window of 15-4,000 kEv (almost any research isotope (F18, C11, Tc99m, 125I, 68Ga 89Zr, 64Cu, etc.))
Belt-driven/robotic arm automated system with a shielded internal sample balance
Machine will tare and weigh empty or full vials and will decay-correct to specified time
Data stored as an excel spreadsheet. Will provide raw counts and also convert to %ID/g or %ID/mL
in vitro radiopharmaceutical binding assays
in vitro radiopharmaceutical accumulation assays
ex vivo tissue biodistribution assays
ex vivo arterial input function
ex vivo metabolite assays
Location and hours of operation
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Links and Resources
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Contacts
Name
Role
Phone
Email
Location
Shivashankar Khanapur
Core Director
krs5xf@virginia.edu
153 Snyder
Radiochemistry Services
Search available services:
Name
Description
Price
[13N]-Ammonia
This service request provides the user up to 30.0 mCi of [13N]ammonia for research use ONLY. Please consult the Core Director, Shivashankar Khanapur (krs5xf@virginia.edu) to inquire for quantities appopriate for study and calibration time.
Inquire
[18F]FDG
This service request provides the user up to 2.0 mCi of [18F]FDG for pre-clinical research use ONLY. Please consult the Core Director, Shivashankar Khanapur (krs5xf@virginia.edu) to inquire for quantities appopriate for study and calibration time.
Inquire
[18F]FDG-human
This service request provides the user one dose of [18F]FDG for human research use ONLY. Please consult the Core Director, Shivashankar Khanapur (krs5xf@virginia.edu) to inquire for quantities appopriate for study and calibration time
Inquire
[18F]NaF
This service provides the user up to 10 mCi of [18F]NaF for research use ONLY. Please consult the Core Director, Shivashankar Khanapur (krs5xf@virginia.edu) for quantity needed and calibration time.
Inquire
Custom Synthesis
This service encompasses custom chemical synthesis the core provides to the user. The core is capable of:
custom organic synthesis of chemical precursors for radiochemical use
custom synthesis of non-radioactive small molecules for research use
organic synthesis of standards for HPLC identity
research and development of custom radiopharmaceuticals for preclinical and clinical research.
This service is billed hourly. Please contact Shivashankar Khanapur (krs5xf@virginia.edu) for questions.
Inquire
RADCHEM-Human
This service provides the investigator with a single dose of radiopharmaceutical for use in clinical research studies. Please contact Shivashankar Khanapur (krs5xf@virginia.edu) before placing an order for this service.
Inquire
RADCHEM-Pre
This service provides the investigator with a production batch of radiopharmaceutical for research use in preclinical models. Depending on the imaging agent ordered, multiple doses may be used from the same production batch for imaging or other relevant work.
Inquire
Support
This service provides general labor support from the radiochemistry core personnel. This may include data gathering, handling, processing, generation of regulatory filings for clinical trials (CMC section, general IND prep) or any other service you may wish to seek the radiochemistry core's expertise. This rate is billed hourly. Please contact Shivashankar Khanapur with any questions.
This service provides the investigator with a single dose of radiopharmaceutical for use in clinical research studies. Please contact Shivashankar Khanapur (krs5xf@virginia.edu) before placing an order for this service.
This service provides the investigator with a production batch of radiopharmaceutical for research use in preclinical models. Depending on the imaging agent ordered, multiple doses may be used from the same production batch for imaging or other relevant work.
This service provides general labor support from the radiochemistry core personnel. This may include data gathering, handling, processing, generation of regulatory filings for clinical trials (CMC section, general IND prep) or any other service you may wish to seek the radiochemistry core's expertise. This rate is billed hourly. Please contact Shivashankar Khanapur with any questions.
This service request provides the user up to 30.0 mCi of [13N]ammonia for research use ONLY. Please consult the Core Director, Shivashankar Khanapur (krs5xf@virginia.edu) to inquire for quantities appopriate for study and calibration time.
This service request provides the user up to 2.0 mCi of [18F]FDG for pre-clinical research use ONLY. Please consult the Core Director, Shivashankar Khanapur (krs5xf@virginia.edu) to inquire for quantities appopriate for study and calibration time.
This service request provides the user one dose of [18F]FDG for human research use ONLY. Please consult the Core Director, Shivashankar Khanapur (krs5xf@virginia.edu) to inquire for quantities appopriate for study and calibration time
This service provides the user up to 10 mCi of [18F]NaF for research use ONLY. Please consult the Core Director, Shivashankar Khanapur (krs5xf@virginia.edu) for quantity needed and calibration time.
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